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Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): Randomised placebo-controlled trial

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10.1021/om500317b 117 PettinariR.MarchettiF.PettinariC.CondelloF.PetriniA.ScopellitiR.et al (2015)

A shift from small molecules towards biopharmaceuticals in major pharmaceutical companies is likely to lead to increased efforts in developing and evaluating strategies to improve the delivery of large molecules to the brain

In the short term, these factors may lead to fluctuations in market dynamics, while the long term could see a reshaping of industry landscapes as companies adapt to overcome challenges and leverage new technologies