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Serine deprivation specifically reduces the mRNA translation efficiency of serine codons TCC and TCT, leading to the selective translation and secretion of nerve growth factor (NGF) by pancreatic cancer cells

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doi: 10.1158/1078-0432.CCR-13-2805 34 LiuXXLiXJZhangBLiangYJZhouCXCaoDXet al

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However, DSIP lacks FDA approval and standardized quality control

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In addition to glycine, D-serine is an NMDA receptor co-agonist, which is supplied by astrocytes (Henneberger et al., de novo synthesis of D-serine (Neame et al., 2019)

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Its activation of intracellular pathways like PI3K-AKT and MAPK, which are essential for cellular proliferation and differentiation, has also drawn the attention of scientists (6)

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Lastly, whole grains such as quinoa, brown rice, and oats can help maintain stable energy levels while aiding digestion and promoting overall health

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