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immune cells are among the most GSH-dependent in the body Redox signalling the GSH/GSSG (reduced/oxidised) ratio is a master regulator of cellular redox state, modulating transcription factors including NF-B and Nrf2 Protein maintenance glutathionylation protects cysteine residues in proteins from irreversible oxidation, preserving enzyme function Glutathione levels decline with age, chronic illness, toxin exposure, and oxidative stress contributing to accelerated cellular aging, impaired detoxification, and systemic inflammation

Nanopolystyrene-induced microRNAs response in Caenorhabditis elegans after long-term and lose-dose exposure

If these symptoms are not addressed quickly through appropriate concussion therapy, chronic brain inflammation can evolve toward more serious neurodegenerative conditions, potentially paving the way for dementia, Parkinsons disease, or Alzheimers disease

FIGURE 3 3.2 Mechanistic insights and emerging evidence linking copper dyshomeostasis to SCM 3.2.1 Oxidative stress Oxidative stress plays a critical role in SCM (Zhang et al., 2022)