Studies have shown that there is a close relationship between the survival of the mitochondrial GSH pool (mGSH) and that of the cells due to the central role of mitochondria in programmed cell death (apoptosis) as well as important involvement of ROS produced at 90% in mitochondria [17]
Figure 2 Besides to reduced free zinc levels, zinc binding to MTs directly protects the sulfhydryl groups of MTs from oxidation
Furthermore, a study has demonstrated neuron-selective delivery of microRNA using a D3-peptide-conjugated nanopolymer injected into the tail vein in an AD mouse model [63]
ORCID: Affiliation: 2 Cell Biology and Physiology, Translational Research Unit of Excellence CSIR, Indian Institute of Chemical Biology, Kolkata 700091, West Bengal, India ORCID: Affiliation: 1 Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, India ORCID: Affiliation: 1 Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, India ORCID: Affiliation: 3 Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, India Email: [email protected]
2, many protein-protein interactions (PPIs) are relatively flat at the site, lack a well-defined binding pocket, and exist at multiple contacts, as is the case for GPVI, which also leads to the identification of small-molecule inhibitors to become challenging
Adsorptive removal of heavy metals from wastewater using cobalt-diphenylamine (Co-DPA) complex
