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In this study, paclitaxel decreased the amount of beneficial bacteria such as Akkermansia muciniphila OTU, which was previously shown to promote the integrity of the epithelial cell layer and improve barrier function [144]

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SREBP1 activation induces stearoyl-CoA desaturase ( SCD1 ) expression, which presumably promotes the accumulation of ferroptosis-inhibitory monounsaturated fatty acids 18 though this connection awaits to be validated by lipidomics