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114 However, the trial was later judged to be at high risk of bias due to unequal treatment groups and a lack of blinded outcome assessment

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Topical use of terpenoids induce ocular irritation and allergic reactions in sensitive individuals, and their poor water solubility and stability can further limit clinical application ( 3.4 Quinone derivatives Thymoquinone (TQ), a quinone derived from Nigella sativa , combines neuroprotective, antioxidant, anti-inflammatory, and anti-fibrotic activities (Sadeghi et al., 2023)