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For these regions, the side chains were stubbed in the final PDB models if no robust density was present in the EM maps

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Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

Overview Lets start with the basics, what amylin is and why it is different from GLP-1 In the Semaglutide and Tirzepatide products we saw how the incretin hormones GLP-1 and GIP regulate appetite and glycemia via the enteroendocrine system (a signal from the gut)

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Collectively, our data provides mechanistic insight into the behaviour of Cagri as a dual CTR and AMYR agonist peptide