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The benefit of this is that this higher dose can be injected in one shot and the benefits of B12 supplementation may be felt sooner

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the predicted binding mode of 1j indicates the C5-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue

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