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As a consequence of IO&NS, some cellular immune functions may be suppressed, for example, lowered natural killer cell activity (NKCA) and ex vivo expression of T cell activation markers, such as CD69

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Acknowledgments The authors would like to acknowledge the Graduate School of Facultad de Ciencias Veterinarias, and Vicerrectoria de Investigacin, Desarrollo y Creacin Artstica, of Universidad Austral de Chile

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10.1016/j.lfs.2013.09.019 3 AcquavivaR.TomaselloB.Di GiacomoC.SantangeloR.La MantiaA.NaletovaI.et al (2021)

Eighteen patients with moderate PD received treatment with ambroxol for 186 days, which resulted in a significant increase in their CSF -syn and GCase concentration levels as well as a significant decrease in UPDRS motor score, while safety and tolerability of the treatment was confirmed (Mullin et al