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Collectively, these findings question the notion that mitochondria are the primary source of ROS production in contracting skeletal muscle and future studies will be required to fully define the role that mitochondria play in exercise-induced production of ROS in muscle

It targets a range of substrates, including misfolded or oxidized proteins, tau, polyglutamine-expanded proteins, and key signaling factors (Lee et al., 2013

Organosulfur compounds Organosulfur compounds mainly present in vegetable species belonging to Allium genus and Brassicaceae family

Abcam), oxidized phosphatidylcholine (E06 mAB-biotinylated, 330002 S

GSH-Grx belongs to the Trx protein family and facilitates the reduction of disulfide bonds to maintain redox homeostasis