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Results and Discussion Reactions of oxaliplatin Oxaliplatin, or [Pt(R,R-DACH)(oxalate)] (R,R-DACH = R,R-cyclohexane-1,2-diamine), is frequently administrated in the treatment of colorectal cancer 28

However, a growing body of evidence suggests that mitochondria are critically involved in necroptosis initiation and execution, including mitROS-mediated RIPK1 and RIPK3 recruitment, feedback RIPK1/RIPK3-mediated mitROS generation, RIPK3-dependent pyruvate dehydrogenase complex-mediated ROS production, or phosphoglycerate mutase family member 5 (PGAM5)-dependent dynamin-related protein 1 (Drp1)-mediated necroptosis (PGAM5 is activated downstream of the RIPK1/RIPK3/MLKL complex) [137,138,139,140]

Darst, S

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[117] tested whether the toxic effects of Mn and arsenic in endothelial cells are additive, where exposure to the mixture would generate an enhanced endothelial cell dysfunction

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