glutathione pathway metabolites Metabolism - an overview Homocysteine metabolism and glutathione (GSH)

2 Mitochondrial GSH import is mediated by SLC25A39

Wei QY, Chen WF, Zhou B, Yang L, Liu ZL (2006) Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues

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The physiological relevance of the kinetic uncoupling is that it allows the formation of stable complexes, for example, with ironsulfur clusters or disulfide-bonded interaction partners

The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

Indeed, we found hypotaurine and serine levels increased in the liver of Gclc KO mice (Fig