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Trial of antisense oligonucleotide Tofersen for SOD1 ALS

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Both MYO-2 and MES-2 share the expression of H19, the long non-coding RNA, known to play an important role in cellular differentiation: H19 is abundant in embryonic tissues, but shortly after birth is significantly downregulated in all tissues but not skeletal muscle, where it is involved in the promotion of myoblasts differentiation and muscle regeneration mediated by the microRNAs embedded within it 32