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By inhibiting NNMT using agents such as 5-amino-1MQ, it's possible to enhance NAD+ levels and activate genes that promote metabolism

Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

As they do, the growth signals they send to the follicle get weaker

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Skipping doses or discontinuing treatment prematurely may affect the desired outcomes

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