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This variant, along with a polymorphic variants in the ferrireductase STEAP3 on chromosome 1 impact redox (glutathione and oxidative PTM) homeostasis in fresh and stored RBCs, delinneating protein markers of the storage lesion and protein, peptide, and PTM correlates to PTR, a marker of transfusion efficacy

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Ubistatin is a small molecule that interacts specificially with polyubiquitin chains and blocks their interactions with receptors on the proteasome