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Methods: Patients within the Childhood Liver Disease Research Network (ChiLDReN) enrolled in the Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) study were identified with BASD by local centers via biochemical evidence based on mass spectrometry analysis of urine/serum or from biallelic pathologic mutations in genes encoding enzymes in the bile acid synthetic pathway

World J Gastroenterol (2015) 21(5):145767

NAD+ is too big and unstable to cross cell walls intact

Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy