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This growing global distribution highlights the urgent need for early detection, preventive screening, and integrative approaches that address both disease management and long-term quality of life [3][2]

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From the present review, it is evident that small peptides exert towards oral cells and tissues an antitumor activity through apoptosis or selective necrosis of cell lines specifically associated with oral squamous cell carcinoma, an antimicrobial function by maintaining the balance of the oral microbiome, an immunomodulatory function through up and down-regulation of important genes involved in immunoregulatory gene cascades, and finally a cell differentiation function towards major stem cells in the oral cavity, even in absence of growth factors [21, 27,28,29,30,31, 34, 35]

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The inf_CNCbl40 group displayed microbial activity that favored the UDP-N-acetylmuramate from fructose-6-phosphate biosynthesis pathway (Fig