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Navigating the regulatory landscape for NP-based therapeutics can also be complex and is still evolving due to the novel nature of these treatments

Register TC, Frye BM, Negrey JD, Johnson CSC, Snyder-Mackler N, Craft S, Montine TJ, Shively CA (2024) Relationships between circulating monocyte and brain transcriptional profiles in nonhuman primates consuming mediterranean versus western like diets

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The UPR and iron starvationlike responses were independent of each other, as the latter persisted in HGT1 ire1 cells that had otherwise lost the UPR (Supplementary Figure S4C and D), but their concurrence probably caused conflicting gene regulation

Its depletion during illness or infection leads to intestinal epithelial cells atrophy resulting in increased intestinal permeability (352)

Ludwig, W., Hayes, S., Trenner, J., Delker, C