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The approval of this first in a new class of cell therapies for solid tumors defines a regulatory path for TIL, which will unlock more innovation in the industry and ultimately benefit patients with cancer, Jason Bock, CEO of CTMC, a joint venture between biotech Resilience and MD Anderson Cancer Center, told BioSpace in an email

For example, MET overexpression has been associated with more invasive advanced tumours in glioblastoma [95] and oesophageal squamous cell carcinoma [96], a significantly increased risk of tumour recurrence in colorectal cancer [97], and reduced survival in glioblastoma [58, 95], colorectal cancer [97] and breast cancer [98, 99]

And it affects glucagon secretion to improve metabolic regulation

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Again, this is preclinical work, but it expands the mechanistic map