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Accessed 11/3/2020, Moskowitz HS, Dinces EA

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The trial group improved more than the control group with 37 grade 1 patients (34.6%), compared with 28 (25.5%) in the control group, and 22 cases (20.6%) of grade 3 patients in the trial group, compared with 34 cases (30.9%) in the control group

High plasma and tissue choline concentrations are common in diseases characterized by chronic low-grade inflammation, supporting the role of choline in modulating immune cell activation and tissue damage ( 3.3.1 Autoimmune and degenerative diseases For instance, in rheumatoid diseases, lipidomic studies in synovial fluid have reported altered phospholipid profiles with enrichment of choline-containing lipids, such as PC (186), which correlate with enhanced ChoK expression and activity

Besides its role in cancer, amino acid metabolism has been reported as an important participant in the development of metabolic diseases such as diabetes and obesity, as well as cardiovascular diseases, autoimmune diseases and neurological diseases

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