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PMID: 29507908

311,312,313 It has recently been demonstrated that MIF inhibits the GC-induced leucine zipper (GILZ) expression via a unique set of effects on transcription factor expression and phosphorylation, and regulation by MIF of MKP-1 and MAPK activation are mediated through GILZ (Fig

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Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH: Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells

This relatively short biological lifespan presents challenges for researchers seeking to investigate sustained amylin receptor activation

By contrast, phase 2 standalone treatment data established proof of concept for substantial weight reduction