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High dose aspirin is uricosuric, while low dose causes urate retention (Roch-Ramel et al., 1997

Under physiological conditions, a healthy gut microbiota and an intact intestinal barrier are critical for establishing immune tolerance ( The tumor immune microenvironment (TIME), a dynamic ecosystem of cancer cells, stromal cells, ECM, and diverse immune cells, profoundly shapes tumor progression and therapeutic responses ( A pivotal mechanism linking gut dysbiosis to pro-tumorigenic inflammation is the translocation of microbial components, most notably lipopolysaccharide (LPS), across a compromised intestinal barrier ( Beyond TLR-dependent microbial sensing, the NF-B pathway serves as a critical signaling hub that integrates diverse pro-tumorigenic stimuli within the TIME

J Cell Mol Med (2017) 21:64857

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Currently, two major hypotheses prevail in terms of FLC and ALC development and differentiation

However, significant challenges remain in translating metabolomic findings into clinical practice, including the standardization of analytical protocols, cross-population validation, and the biological interpretation of complex datasets