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Some adverse effects may originate from the off-target proteins

Asian J Surg 43(2):405416 Fagundes FL, Piffer GdM, Prico LL, Rodrigues VP, Hiruma-Lima CADos Santos RdC, (2020) Chrysin modulates genes related to inflammation, tissue remodeling, and cell proliferation in the gastric ulcer healing

& Pietrobon, D

Research suggests these multi-organ observations might indicate systemic cytoprotective signaling engagement rather than tissue-localized activity restricted to the gastrointestinal compartment