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Likewise, anticoagulants can often lower and moderate inflammation

P62 competitively binds to Keap1, thereby relieving the latters inhibition of Nrf2 and facilitating Nrf2 nuclear translocation to activate antioxidant gene expression, ultimately enhancing cellular antioxidant capacity

Lipid peroxidation damages mitochondrial membranes and disrupts mitochondrial function, leading to insufficient energy supply in muscle cells, which exacerbates muscle atrophy and the onset of sarcopenia (39)