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Deficiency causes fat accumulation in the liver but supplementation in non-deficient people has not demonstrated significant fat loss effects in well-designed human trials

When liver function deteriorates significantly, the combination of released stored B12, increased circulating haptocorrin, and reduced hepatic clearance can result in markedly elevated total serum B12 levels

Why Testosterone Therapy Causes Polycythemia Testosterone stimulates erythropoiesis (red blood cell production), partly through increasing erythropoietin and enhancing bone marrow activity