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179 Interestingly, ROCK inhibitor was also shown to inhibit lipopolysaccharide (LPS)-induced MLC phosphorylation and occludin downregulation

90 A recent study revealed that senescent HSCs in young mice following PHx promote liver repair through multiple signaling pathways induced by the expression of the senescence-associated secretory phenotype

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and epithelial protective cytokine IL-22 in UC mice [72]

If theres less of this protein, certain drugs like cancer treatments, methotrexate, and statins can build up in the body and potentially lead to drug poisoning