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Depending on the severity of the symptoms, a hangover can be mild (with a slight headache and fatigue or just general discomfort), moderate (moderate-to-severe headache, nausea, vomiting, irritability, fatigue, and dehydration),or severe (intense and severe headache, mood swings, anxiety, dizziness, severe nausea and vomiting, impaired concentration, muscle pain, extreme weakness, and fatigue)

Acknowledgements This work was supported by National Research Foundation of Korea (NRF) grants NRF-2021R1A2C3005603, 2020R1A5A2017323, NRF-2022R1A2C1008591, and NRF-2021R1C1C2003405 funded by the Ministry of Science and ICT

Nature (2013) 497:4517

Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification