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While this review focuses on ADA as an important outcome of mAb immunogenicity, there are other immunogenicity outcomes such as allergic reactions, cytopenia, and anaphylaxis that are widely reviewed elsewhere ( The Molecular Mechanisms That Lead to ADA Formation Anti-drug antibodies can be generated by a T-cell dependent or independent B cell activation pathway

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LL-37 can be degraded by bacterial and host proteases, has demonstrated toxicity to host cells at high concentrations, and is costly to synthesize at scale