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This mutation was reported in 2017 in a study assessing the genetic heterogeneity of NS5B by ultra-deep pyrosequencing in patients harbouring GT3a not achieving SVR

However, under certain pathological conditions, excessive changes in organ weight due to organ congestion and oedema, hyperplasia and hypertrophy, atrophy or degeneration will occur

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Instead, carnitine assists the transport and metabolism of fatty acids into mitochondria, and in so doing, carnitine maintains a balance between free and esterified CoA, as an excess of acyl-CoA intermediates is potentially toxic to cells

However, the mode(s) of action for these compounds remains obscure as it is unclear which of the myriad NS5A functions are inhibited