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Interestingly, bortezomib, a potent proteasome inhibitor known to increase microtubule polymerization in neuronal cell line (Poruchynsky et al., 2008), also induced excessive microtubule polymerization in the cell bodies of DRG neurons by increasing hyper-stable delta 2 tubulin (D2) (Pero et al., 2021)

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Moreover, PT restored mitochondrial morphology, enhanced mitochondrial membrane potential, decreased ROS accumulation, increased ATP production and respiratory efficiency, and promoted mitophagy

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