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Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J, Gallinger S, Lindor NM, Casey G, Ellis N, Giardiello FM, Offit K, Parmigiani G: Prediction of germline mutations and cancer risk in the Lynch syndrome

The mechanism mainly involves AKT in inactivating GSK-3 and reducing the phosphorylation levels of NF-B p65 subunit at Ser529 and Ser536 sites, thereby inhibiting the transcriptional activity of NF-B (Zhao et al., 2008)

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Ferroptosis is characterized by glutathione depletion and the impairment of glutathione peroxidase 4 activity, which hinders the detoxification of lipid hydroperoxides

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44,45 Conversely, physiological cardiac hypertrophy is an adaptive and reversible cardiac growth that appears upon chronic exercise stimulation and exerts cardiac protective effects