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In silico studies shows that berberine interacts with key oncogenic proteins such as p53, EGFR, AKT, p38, and ERK1/2, while in vitro experiments validated its ability to decrease the phosphorylation of these proteins, highlighting its potential as an effective treatment for oral squamous cell carcinoma and breast cancer [196, 197]

Nutrients, 14(9), 1770

Collins MA, Bednar F, Zhang Y, Brisset JC, Galbn S, Galbn CJ, et al

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells

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