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Senescent TECs upregulate cyclin-dependent kinase inhibitor 2 A (p16), 1B (p27), and 1 A (p21) and secrete diverse cytokines and growth factors via the SASP

Diabetologia 48 , 838848 (2005)

This wider therapeutic value makes up for the higher initial cost for many patients who want to improve their overall health

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice