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These should be minimised or avoided, particularly in the early weeks of treatment

Notably, increased NAD+ levels also activate NAD+dependent signaling pathways such as sirtuins (SIRT1/SIRT3), further enhancing mitochondrial biogenesis and energy metabolism

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In each instance the total number of spines was counted for the treatment groups, control, Nle1-AngIV and Dihexa, to ensure an active phenotype