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Pyruvate kinase deficiency varies significantly in severity, from a mild, compensated condition requiring little intervention to a severe disease requiring transfusions

Current therapeutic approaches, such as disease-modifying anti-rheumatic drugs (DMARDs) and biologics, are limited by infection risks, poor tissue specificity, and suboptimal long-term efficacy, underscoring the need for novel therapies

These compounds do not form covalent bonds with the substances to which they are added, so they can easily migrate and penetrate various everyday products

These carriers can be sealed with a nanolid made up of H 2 O 2 responsive AgNPs and in the TME, high concentration of H 2 O 2 triggers the removal of cap and release of loaded drug [86]

Hashizume, H

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