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Muscle weakness and reduced strength Low vitamin B12 levels can lead to muscle weakness, particularly in the legs

This approval may offer greater flexibility for healthcare providers and people living with multiple sclerosis, based on their individual treatment needs, Roche CMO Levi Garraway said in a statement

The majority of people who take this medicine do not have any substantial adverse effects

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Users stopping niacinamide typically experience very gradual benefit decline over 1-3 months without dramatic reversal, maintaining 40-60% of improvements long-term if treatment lasted 6+ months, and tolerating breaks or cycling without rebound effects or significant regression concerns