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Last updated April 2026 Medically reviewed by Ana Reisdorf, MS, RD Sources verified against the Zepbound FDA prescribing information, NEJM SURMOUNT-1 (Jastreboff 2022), JAMA SURMOUNT-4 (Aronne 2023), and Lillys Zepbound consumer page

Some people take B12 injections short-term to correct a deficiency, while others use them long-term for ongoing support, especially if they have: We recommend getting lab tests periodically to assess B12 levels and determine if continued supplementation is necessary