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A plethora of clinical trials using tocilizumab is currently ongoing in relation to COVID-19 (Actemra, Roche, NCT04317092, NCT04320615, etc.)

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These mutations, which primarily affect IDH1 (R132), which is localized in the cytosol and peroxisomes, and IDH2 (R172), which is located in the mitochondria, lead to the accumulation of D-2-hydroxyglutarate metabolites, driving oncogenesis through widespread epigenetic dysregulation