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As an oxidoreductase, FSP1 uses NAD(P)H to reduce CoQ10 to ubiquinol (CoQ10H2) on cell membranes, generating lipophilic radical-trapping antioxidants that suppress ROS and LPO, countering ferroptosis (Kraft et al., 2020

The rate of de novo synthesis is responsive to environmental factors

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Furthermore, the accumulation of malondialdehyde, a marker of oxidative stress, has been observed in patients with -thalassemia, indicating heightened oxidative damage (77)

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This Ca signature is detected by Ca sensors and then a downstream signal is transduced that subsequently enhances the defense mechanisms [65]