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However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes

Biliverdin is converted into bilirubin, a strong antioxidant, whereas carbon monoxide has anti-inflammatory properties [31]

It is well known that CDDP acts on multiple cellular targets representing diverse signal transduction pathways

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doi: 10.1186/s12967-022-03566-6