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Other studies have found that the more components of the MetS are present, the greater the risk of developing CVD [42, 53, 61]

The long-term effects of residual Pt in the joint cavity on cartilage and synovium need thorough assessment

Isolation of mitochondria from tissues Freshly dissected brain tissue was cut into smaller pieces, rinsed in cold PBS, and homogenized using either a Dounce homogenizer or Waring blender in the presence of twice the tissue volume of buffer A (20 mM Hepes pH 7.4, 220 mM mannitol, 68 mM sucrose, 80 mM KCl, 0.5 mM EGTA, 2 mM Mg(Ac) 2 , 1 mM DTT, 1 protease inhibitor (Roche))

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Therefore, our findings may also ignite future researches in verifying the potential protective benefits of MeCbl against GSDME mediated pyroptotic injury of other organs