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Time in therapeutic range is significantly greater (56%-93%) in patients managed by anticoagulation clinics, among self-testing and self-monitoring patients, and in patients managed with the help of computer programs.25Self-testing patients had fewer bleeding events than patients in usual care.25 The management of patients who undergo dental and surgical procedures requires close liaison between attending physicians, surgeons and dentists.15, 19PT/INR determination is recommended just prior to any dental or surgical procedure

Shaking can denature the peptide and reduce potency

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