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Phase III clinical trials, most notably the 6-month randomized controlled study, revealed a significant dose-dependent adverse effect: while conservative dosing (20 mg/kg/day) stabilized cardiac indices, aggressive chelation (40 mg/kg/day) precipitated a significant worsening of ataxia and neurological symptoms [119]

Finally, these tumour fragments were thawed and grafted into recipient immunocompetent C57BL/6 mice and used for the designated experimental treatments

Informed consent was obtained from all the participants

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A single-center cohort study measured the incidence of VTE in a cohort of 198 hospitalized patients who showed evidence of thrombotic complications including D-dimer elevation, symptomatic PE, and VTE associated mortality in the ICU [63]