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Supplementary Material Acknowledgments This research was supported in part by National Institutes of Health (NIH) grants CA222963 and CA250101, a Melanoma Research Alliance Foundation established investigator award, and a Chicago Biomedical Consortium Catalyst Award to BZ

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Mitophagy in Ischemic Brain Injury In ischemic brain injury, the interruption of blood supply deprives cells of essential oxygen and nutrients, leading to abnormal cell metabolism, energy depletion, and oxidative stress, ultimately resulting in cell death

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Men are encouraged to adopt healthier habits, such as quitting smoking, reducing alcohol consumption, managing stress, and improving their diet