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[] Increased activity of microglial cells (inflammatory processes, phagocytosis, disruption of the bloodbrain barrier and increased synthesis of oestrogen) was linked to increased ROS and unstable behaviours in mice

This distinction has some implications for our model

Hypoxia, HIF1 and glucose metabolism in the solid tumour

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Omaveloxolone was therefore specifically synthesized and pharmacologically optimized to eliminate this fluid-retaining liability while maintaining target selectivity, making it suited for the highly vulnerable cardiac and neurological landscape of FRDA [108,112]