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What may improve includes: Pain intensity and frequency Radiating symptoms (sciatica) Morning stiffness and mobility Tolerance for sitting, standing, and daily activities Sleep quality affected by pain Dependence on pain medications Many users with disc herniations report 50% to 80% improvement in symptoms while their imaging findings remain unchanged

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Tell your doctor about any medical conditions, as CoolTone should not be used over the uterus during menstruation, over areas of the skin that lack normal sensation, or in patients with fever, cancer, bleeding disorders, active infections, epilepsy, recent surgery, lung problems, or pregnancy

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Additionally, in situ ligand minimization was included in the protocol, where all protein residues within 6 of the ligand were treated as flexible