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According to the gutbrain axis framework, such microbial disturbances may influence the central nervous system (CNS) through interconnected pathways involving neurotransmitter regulation, endocrine signaling, and systemic/neuroinflammation [11]

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The genetically determined deficiencies in GSTs might be a risk factor for the idiosyncratic adverse drug reactions resulting from the formation of reactive drug metabolites [34]

As mentioned, presence of a hypopyon could represent intraocular involvement

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In vertebrates, the innate (non-specific) immune system is one of the two main immunity systems, the second is the adaptive immune system