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Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide

Furthermore, a recent MRS-PET study found that GSH levels in the parietal lobe were negatively correlated with A accumulation in healthy individuals 49

Enzymatic and immunological measurements of soluble and membrane-bound phospholipid-hydroperoxide glutathione peroxidase

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This is also observed in mild cognitive impairment (MCI) which is a preclinical stage of AD

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