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It has been shown that deletion of T Cell Receptor Alpha Constant (TRAC), B2M, and PDCD1 in universal EGFRvIII and CD19-CAR-T cells enhanced their anti-tumor responses, respectively, against both solid and hematologic malignancies (glioblastoma and leukemia)

Hirono A, Iyori H, Sekine I, Ueyama J, Chiba H, Kanno H, Fujii H, Miwa S: Three cases of hereditary nonspherocytic hemolytic anemia associated with red blood cell glutathione deficiency

Takada, M., Fujimoto, M., Yamazaki, K., Takamoto, M., & Hosomi, K

Mitochondrion 54 , 17 (2020)

Following GF-MKD intervention, plasma levels of L-leucine and coumarin decreased by approximately 46% and 60%, respectively, while betaine levels showed a modest increase

It simply highlights the urgent need for larger, well-funded, multi-disciplinary research to bridge the gap between environmental health and mainstream clinical practice