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The first pathway involves remethylation catalyzed by the vitamin B 12 -dependent methionine synthase, which captures a methyl group from the folate-dependent one-carbon pool (5-methyltetrahydrofolate)

Proc Natl Acad Sci 119(51):e2209643119 Huang F, Wu Z (2015)

Consistently, insulin resistance is a common feature in cachectic patients and animals (Tisdale, 2009

In addition to the impacts of red meat and processed meats, other dietary habits are also associated with the incidence of pancreatic cancer [48]

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Pediatric Patients: Dosing is weight-based (10-20 mg/kg), similar to adults, but requires careful monitoring of growth and metabolic markers